603 papers
This study demonstrates that the Arp2/3 complex in postnatal myofibers actively drives muscle growth by generating membrane protrusions that facilitate the fusion of satellite cell-derived myoblasts, thereby establishing myofibers as autonomous regulators of their own nuclear accretion.
This study reveals that Transcription Termination Factor 2 (TTF2) acts as a conserved regulator that ensures proper transcriptional shutdown and prevents premature RNA Polymerase I reactivation during mitotic exit, thereby coordinating the timely resumption of rRNA synthesis and maintaining nucleolar integrity.
This study reveals that in ATM-deficient cells, the BRCA1-A complex restricts replication fork reversal to suppress end-resection and enforce hypersensitivity to Topoisomerase I inhibitors, whereas loss of BRCA1-A restores fork reversal and resection, thereby conferring drug resistance.
This study reveals that miR-378a and NPNT coordinately regulate podocyte autophagy through distinct mechanisms, with miR-378a enhancing flux via mTOR inhibition and NPNT modulating it through MAPK-dependent signaling, offering new insights into the molecular drivers of glomerular diseases.
This study reveals that nascent transcripts from a specific LL2R tandem repeat array on chicken chromosome 2 act as architectural RNAs that nucleate locus-specific, membraneless RNP condensates by recruiting splicing factors while excluding specific hnRNPs, thereby providing a mechanistic model for the formation of nuclear speckles and stress bodies.
This study identifies N-acylphosphatidylethanolamines (NAPEs) as endogenous regulators that inhibit LRRK2 kinase activity to restore lysosomal homeostasis and clear alpha-synuclein aggregates, revealing a promising metabolic axis for Parkinson's disease therapeutics.
This study identifies the depletion of bis(monoacylglycero)phosphate (BMP) and the accumulation of its precursor lysophosphatidylglycerol (LPG) as universal, clinically accessible biomarkers for CLN5 Batten disease, confirming CLN5's role as the essential lysosomal BMP synthase and enabling early diagnosis and patient screening via plasma and dried blood spots.
This study reveals that the simultaneous genetic ablation of SOS1 and SOS2 in mice causes lethal septicemia due to compromised intestinal barrier integrity and stem cell depletion, a phenotype that can be rescued by therapeutic interventions enhancing cellular stemness.
This study identifies Drak as a potential binding partner of Drosophila Filamin that interacts with its mechanically activated conformation and partially colocalizes during embryonic cellularization and flight muscle development, although a direct functional correlation between the two proteins could not be established.
This study introduces CaRPOOL, a high-throughput CRISPRi screening platform that integrates CaMPARI2 to capture transient calcium signals, enabling the discovery of CCR7 as a novel GPCR that modulates cellular osmomechanosensing through a PIEZO1-dependent pathway.